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DeCS
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Descriptor English:
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Cyclic Nucleotide Phosphodiesterases, Type 2
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Descriptor Spanish:
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Fosfodiesterasas de Nucleótidos Cíclicos Tipo 2
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Descriptor Portuguese:
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Nucleotídeo Cíclico Fosfodiesterase do Tipo 2
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Tree Number:
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D08.811.277.352.640.150.200
D08.811.277.352.640.155.200
D12.644.360.008.200
D12.644.360.009.200
D12.776.476.008.200
D12.776.476.009.200
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Definition English:
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A cyclic nucleotide phosphodiesterase subfamily that is activated by the binding of CYCLIC GMP to an allosteric domain found on the enzyme. Multiple enzyme variants of this subtype can be produced due to multiple alternative mRNA splicing. The subfamily is expressed in a broad variety of tissues and may play a role in mediating cross-talk between CYCLIC GMP and CYCLIC CMP pathways. Although the type 2 enzymes are classified as 3',5'-cyclic-AMP phosphodiesterases (EC 3.1.4.17), members of this class have additional specificity for CYCLIC-GMP. |
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History Note English:
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2008(2000)
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Allowable Qualifiers English:
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Record Number:
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52677
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Unique Identifier:
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D054678
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Occurrence in VHL:
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Similar:
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DeCS SciELO LILACS LIS
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